The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may cause a rise in methadone plasma concentrations, which could induce likely deadly respiratory despair. On top of that, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally result in an increase i